Integrating real-time in vivo tumour genomes for longitudinal analysis and management of glioma recurrence Moreover, the TISF ctDNA detected before post-operative anti-tumour treatment probably mirrored the molecular residue and complemented tumour tissues for the spatial architecture of the genome of primary gliomas (Figure 1B). (B) The preoperative situation: The tumour m represents a glioma in the brain parenchyma with relatively lower burden, n and o stand for tumours abutting the CSF reservoir, while the tumour p is one located at the high-risk region of the brainstem. Tumour recurrence is the leading cause of glioma mortality. [Extracted from the article]