Paediatric idiopathic nephrotic syndrome (INS), commonly described histopathologically as minimal change disease, is one of the most common glomerular diseases in children [[1]]. We have shown here that urinary podocyte-derived LEVs can differentiate relapse and remission in children with INS and may act as early warning markers of disease. As such, we sought to quantify urinary podocyte-derived LEVs in a consecutively enrolled cohort of 14 paediatric patients with INS, all of whom contributed a relapse sample and a remission sample. [Extracted from the article]