Background: Rising costs of cancer treatments challenge even areas with universal health coverage. There's a need to assess current medical care utilization trends among patients with cancer to guide public health policy, resource allocation, and set informed healthcare goals. Methods: We analyzed the latest trends in medical care utilization by cancer patients in four areas—drugs, radiation therapy (RT), surgery, and diagnostic procedures—using clinical databases extracted from electronic medical records of a tertiary hospital in Korea between 2014 and 2019. Compound adjusted growth rates (CAGR) were computed to capture the annual growth over the study period. Results: A total of 74,285 cancer patients were identified, with 40.3% (29,962), 14.2% (10,577), 31.1% (23,066), and 92.6% (68,849) of patients having received at least one anticancer agent, RT, surgery, and diagnostic procedure, respectively, over the period. We observed a 1.7‐fold increase in the use of targeted · immune‐oncology agents (from 6.8% to 11.6%) and a 21‐fold increase (from 3.0% in 2014 to 65.7%) in intensity‐modulated RT (IMRT) use over the period. In contrast, we observed a continuous decrease in the proportion of patients who underwent surgical treatment from 12.2% in 2014 to 10.9% in 2019. This decrease was particularly noticeable in patients with colon cancer (from 28.5% to 24.2%) and liver cancer (from 4.1% to 2.9%). Conclusion: From 2014 to 2019, there was a significant rise in the use of targeted · immune‐oncology agents and IMRT, alongside a decline in surgeries. While targeted · immune‐oncology agents and IMRT may offer promising outcomes, their financial impact and potential for overuse necessitate careful oversight and long‐term cost‐effectiveness studies. [ABSTRACT FROM AUTHOR]