Confinement and manipulation of individual molecules in attoliter volumes.
- Resource Type
- Article
- Authors
- Kung, C.-Y.; Barnes, M.D.; Lermer, N.; Whitten, W. B.; Ramsey, J. M.
- Source
- Analytical Chemistry. 02/01/98, Vol. 70 Issue 3, p658. 4p. 4 Graphs.
- Subject
- *FLUORESCENCE
*ELECTRONIC probes
- Language
- ISSN
- 0003-2700
Discusses how individual florescence molecules can be confined and efficiently probed in volumes of solution (~500 aL)roughly equal to illumination volumes defined by diffraction-limited high-numerical-aperture optics. Potential of single-molecule probe as bioanalytical tools; Development of several experimental approaches to single-molecule fluorescence detection and imaging in liquids.