Assessing the impact of the 2017 European LeukemiaNet recommendations on FLT3 allelic ratio calculation and reporting in acute myeloid leukaemia.
- Resource Type
- Article
- Authors
- Cartwright, Ashley; Scott, Stuart; Francis, Sebastian; Whitby, Liam
- Source
- British Journal of Haematology. May2022, Vol. 197 Issue 3, pe35-e37. 3p.
- Subject
- *ACUTE myeloid leukemia
*HEMATOPOIETIC stem cell transplantation
- Language
- ISSN
- 0007-1048
I FLT3 i internal tandem duplications ( I FLT3 i -ITDs) are the most common genetic aberration identified in acute myeloid leukaemia (AML) and have historically been associated with higher relapse rate and lower overall survival in AML.1 European LeukemiaNet recommendations (ELN) for the diagnosis and prognosis of AML outline three risk stratification groups as a method of standardising the reporting of genetic abnormalities relating to the clinical disease characteristics and prognostics.2 The risk stratification groups outline the differing clinical outcomes depending on the presence/absence of genetic markers. Sixteen (30.8%) report each I FLT3 i -ITD AR separately and eight (15.4%) participants reported both separate and combined I FLT3 i -ITD AR to clinicians. The clinical significance of multiple I FLT3 i -ITDs in AML patients is unclear in the I FLT3 i inhibitor era. [Extracted from the article]