Rh‐catalyzed Asymmetric C(sp3)−H Arylation of 8‐Benzylquinolines with Arylboronic Acids.
- Resource Type
- Article
- Authors
- Zhang, Zuo‐Yu; Gou, Bo‐Bo; Wang, Quannan; Gu, Qing; You, Shu‐Li
- Source
- Advanced Synthesis & Catalysis. 2/20/2024, Vol. 366 Issue 4, p774-779. 6p.
- Subject
- *ARYLATION
*FUNCTIONAL groups
*RHODIUM
*ACIDS
- Language
- ISSN
- 1615-4150
Rh‐catalyzed asymmetric C(sp3)−H arylation of 8‐benzylquinolines with arylboronic acids was developed. In the presence of 5 mol% BINOL‐derived chiral cyclopentadienyl rhodium complex, asymmetric benzylic C(sp3)−H bond arylation reaction proceeded smoothly to afford a series of enantioenriched triarylmethanes in moderate to good yields with good to excellent enantioselective control (24–89% yields, 63–93% ee). The method displays a broad substrate scope and good functional group tolerance under mild conditions. [ABSTRACT FROM AUTHOR]