In 2017, the World Health Organization (WHO) formally listed snakebite envenoming (snakebite hereafter) as a NTD, adding it to the global health agenda and marking an important shift in both awareness and control efforts [[1]]. We explore how human health, animal health, and reliance on agricultural activity and domestic animals for livelihood should be considered in a One Health approach. In the human health dimension, available national estimates place snakebite as a leading cause of health burden due to NTDs in terms of disability-adjusted life years [[14]]. DIAGRAM: Fig 1: Pathways to health and livelihood losses due to snakebite in a One Health approach to the socioeconomic impact assessment of snakebite. [Extracted from the article]