Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts.
- Resource Type
- Article
- Authors
- Wada, Takuma Tsuzuki; Araki, Yasuto; Sato, Kojiro; Aizaki, Yoshimi; Yokota, Kazuhiro; Kim, Yoon Taek; Oda, Hiromi; Kurokawa, Riki; Mimura, Toshihide
- Source
- Biochemical & Biophysical Research Communications. Feb2014, Vol. 444 Issue 4, p682-686. 5p.
- Subject
- *HISTONE acetylation
*INTERLEUKIN-6
*RHEUMATOID arthritis
*FIBROBLASTS
*PROMOTERS (Genetics)
*EPIGENETICS
- Language
- ISSN
- 0006-291X
Highlights: [•] IL-6 production is elevated in rheumatoid arthritis synovial fibroblasts. [•] Histone H3 acetylation is increased in the IL-6 promoter. [•] The reduction in histone H3 acetylation decreases IL-6 production. [•] We report epigenetic aberrations in the pathogenesis of rheumatoid arthritis. [ABSTRACT FROM AUTHOR]