Monocyte subsets in the production of inhibitory factor by Candida albicans-activated human T cells.
- Resource Type
- Article
- Authors
- Lombardi, Giovanna; Plccolella, Enza; Vismara, Daniela; Colizzi, V.; Zembala, M.
- Source
- Immunology. Oct85, Vol. 56 Issue 2, p373-376. 4p.
- Subject
- *MACROPHAGES
*LYMPHOCYTES
*CANDIDA albicans
*RETICULO-endothelial system
*CONNECTIVE tissue cells
*ANTIGEN presenting cells
- Language
- ISSN
- 0019-2805
Macrophages are essential for the proliferative response of human T lymphocytes to a purified polysaccharide extract from Candida albicans (MPPS). The role of macrophages as antigen-presenting cells in the production of an antigen non-specific inhibitory factor (nsINH) by MPPS-activated I cells was also investigated. Fc receptor positive (FcR+) or negative (FcR+) plastic-adherent mononuclear cells were used as MPPS-presenting cells, and the results show that the FcR+ subset is mainly responsible for the release of nsINH from activated T cells. [ABSTRACT FROM AUTHOR]