Patients with HHD generally require life-long treatment, and the goal of treatment is to manage their symptoms and prevent flares from occurring. This unexpected clearance of our patient's HHD warrants the investigation of using ocrelizumab or the closely related agent rituximab as potential treatment options in severe cases of this rare condition. Https://doi.org/10.1093/bjd/ljad101 Dear Editor, Benign familial pemphigus, also known as Hailey-Hailey disease (HHD), is a rare autosomal-dominant genetic skin disorder characterized by symmetrical, well-demarcated, erythematous, painful erosive and crusted plaques in the intertrigous regions. [Extracted from the article]