Vacuolated lymphocytes as initial presentation of angioimmunoblastic T-cell lymphoma The cytological aspect of peripheral blood in AITL typically exhibits a polymorphous pattern with a small number of clonal T cells and numerous reactive lymphocytes, plasma cells, and eosinophils, although atypical cases can lack this pattern and may present with the predominant presence of lymphomatous cells on the blood film. This case reminds us that vacuolated lymphocytes in an adult should raise a suspicion of lymphoma, and highlights the importance of a thorough cytological examination combined with blood immunophenotyping to confirm a T-cell lymphoma diagnosis and to distinguish this from other types of lymphoma. [Extracted from the article]