Low CD4+ T Cell Nadir Is an Independent Predictor of Lower HIV-Specific Immune Responses in Chronically HIV-1-Infected Subjects Receiving Highly Active Antiretroviral Therapy.
- Resource Type
- Article
- Authors
- Siddique, M. Atif; Hartman, Kelly E.; Dragileva, Ella; Dondero, Marla; Gebretsadik, Tebeb; Shintani, Ayumi; Peiperl, Laurence; Valentine, Fred; Kalams, Spyros A.
- Source
- Journal of Infectious Diseases. 9/1/2006, Vol. 194 Issue 5, p661-665. 5p.
- Subject
- *T cells
*CELL-mediated lympholysis
*HIV
*HIV-positive persons
*IMMUNE response
*ANTIVIRAL agents
- Language
- ISSN
- 0022-1899
The influence of CD4+ T cell nadirs on human immunodeficiency virus (HIV)-specific immune responses in subjects with apparently normal CD4+ T cell counts is not known. We evaluated the frequency of HIV-1-specific immune responses in a cohort of patients with complete viral suppression (HIV-1 RNA load, <50 copies/mL) who were receiving highly active antiretroviral therapy and had a wide range of CD4+ T cell nadirs. We found positive associations between CD4+ T cell nadirs and the magnitude of HIV-specific CD8+ T cell responses (P = .02 ) and of T cell helper responses (P = .04). These data show the CD4+ T cell nadir to be an independent predictor of HIV-specific CD4+ and CD8+ T cell responses in HIV-1-infected subjects with optimal suppression of viremia. [ABSTRACT FROM AUTHOR]