Computational fluid dynamic simulation of axial and radial flow membrane chromatography: Mechanisms of non-ideality and validation of the zonal rate model.
- Resource Type
- Article
- Authors
- Ghosh, Pranay; Vahedipour, Kaveh; Lin, Min; Vogel, Jens H.; Haynes, Charles; von Lieres, Eric
- Source
- Journal of Chromatography A. Aug2013, Vol. 1305, p114-122. 9p.
- Subject
- *COMPUTATIONAL fluid dynamics
*SIMULATION methods & models
*CHROMATOGRAPHIC analysis
*PREDICATE calculus
*CHROMATOGRAMS
*PARAMETER estimation
- Language
- ISSN
- 0021-9673
Highlights: [•] Rigorous, mechanistic CFD modeling of membrane chromatography capsules at different scales. [•] Prediction of experimental data with a minimal number of regressed parameters. [•] Separate quantification of the impacts of non-ideal flow and non-ideal binding on the resulting chromatograms. [•] Model-based scale-up by transferring binding related parameters across capsule geometries. [•] Validation of the previously published zonal rate model (ZRM). [ABSTRACT FROM AUTHOR]