HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients.
- Resource Type
- Article
- Authors
- Rivera-Peña, Bianca; Ruíz-Fullana, Francisco J.; Vélez-Reyes, Germán L.; Rodriguez-Benitez, Rosa J.; Marcos-Martínez, María J.; Trinidad-Pinedo, Juan; Báez, Adriana
- Source
- Infectious Agents & Cancer. 8/24/2016, Vol. 11, p1-9. 9p. 3 Charts, 6 Graphs.
- Subject
- *PAPILLOMAVIRUS disease diagnosis
*FISHER exact test
*EVALUATION of medical care
*ONCOGENES
*PAPILLOMAVIRUS diseases
*PAPILLOMAVIRUSES
*POLYMERASE chain reaction
*PROGNOSIS
*REGRESSION analysis
*SQUAMOUS cell carcinoma
*SURVIVAL analysis (Biometry)
*PROPORTIONAL hazards models
*KAPLAN-Meier estimator
*OROPHARYNGEAL cancer
- Language
- ISSN
- 1750-9378
Background: HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients. Methods: HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher's exact test and x². Survival analysis was completed using Kaplan-Meier estimator and multivariate Cox regression analysis. Results: OS of HPV-16 positive patients was longer compared to HPV-16 negative patients (P = 0.002). HPV-16 positive tumors of the larynx (LSCC) and pharynx (PSCC) showed improved OS compared to HPV-16 negative tumors. Also, HPV-16 positive patients exposed to radiotherapy presented a better survival. Conclusions: HPV-16 status has a positive prognostic value in HNSCC. Addition of HPV-16 status to the TNM staging can provide better assessment in prognosis and guide treatment for HNSCC patients. [ABSTRACT FROM AUTHOR]