Genome sequence of a chimpanzee herpesvirus and its relation to other primate alphaherpesviruses.
- Resource Type
- Article
- Authors
- Severini, Alberto; Tyler, Shaun; Peters, Geoffrey; Black, Darla; Eberle, R.
- Source
- Archives of Virology. Aug2013, Vol. 158 Issue 8, p1825-1828. 4p. 1 Diagram, 1 Graph.
- Subject
- *HERPESVIRUS diseases in animals
*CHIMPANZEES
*NUCLEOTIDE sequence
*HERPES simplex virus
*VIRUS isolation
*VIRAL evolution
*VIRUS phylogeny
*DISEASES
- Language
- ISSN
- 0304-8608
This study reports the complete genome sequence of chimpanzee herpesvirus (ChHV), an alphaherpesvirus isolated from a chimpanzee. Although closely related to human herpes simplex virus type 2 (HSV2), the level of sequence diversity confirms that ChHV is sufficiently distinct to be considered a member of a different virus species rather than a variant strain of HSV2. Phylogenetic comparison with other simplexviruses at several levels supports the hypothesis that HSV2 and ChHV co-evolved with their respective human and chimpanzee hosts and raises questions regarding the evolutionary origins of HSV1. [ABSTRACT FROM AUTHOR]