In recent decades, there has been an unprecedented increase in knowledge of the previously neglected field of primary immunodeficiency diseases (PID) in developed countries, particularly in Western Europe and the USA [[1]]. The J Project (JP) program was implemented in Central Europe in 2004, to overcome the problem of PID underdiagnosis and undertreatment in most countries in this part of the world [[2]]. In the following year, two more JP meetings were organized, in Tashkent and Samarkand, and a PID working group and a PID-oriented laboratory were set up in Tashkent. [Extracted from the article]