Conclusions COVID-19 and PE exhibit distinctive profiles of endothelial damage, immune dysregulation and angiogenic imbalance, which could help in the differential diagnosis and development of new therapeutic strategies. Methods Plasma and sera samples were obtained from pregnant women with COVID-19 infection classified into mild (n=10) or severe (n=9) in addition to normotensive pregnancies as controls (n=10) and patients with PE (n=13). To study endothelial damage, microvascular thrombosis, immune response and angiogenic imbalance in pre-eclampsia (PE) and COVID-19 in pregnancy. [Extracted from the article]