Comparison of Antifungal Properties of Gold, Silver, and Selenium Nanoparticles Against Amphotericin B-Resistant Candida glabrata Clinical Isolates.
- Resource Type
- Article
- Authors
- Lotfali, Ensieh; Toreyhi, Hossein; Sharabiani, Kamyab Makhdoomi; Fattahi, Azam; Soheili, Amirali; Ghasemi, Reza; Keymaram, Mahyar; Rezaee, Yasaman; Iranpanah, Sayna
- Source
- Avicenna Journal of Medical Biotechnology. Jan-Mar2021, Vol. 13 Issue 1, p47-50. 4p.
- Subject
- *AMPHOTERICIN B
*ANTIFUNGAL agents
*CANDIDA
*CELL physiology
*DRUG resistance in microorganisms
*GOLD
*MICROSCOPY
*NANOPARTICLES
*PATHOLOGICAL laboratories
*SELENIUM
*SILVER
- Language
- ISSN
- 2008-2835
Background: The present study aimed to investigate the antifungal activity of Nanoparticles (NPs) against amphotericin B-resistant Candida glabrata (C. glabrata) strains. Methods: Twelve resistant (C. glabrata) strains were isolated from archived clinical isolates. Antifungal activity was conducted according to Clinical and Laboratory Standards Institute's (CLSI) guidelines, document M27-A3/S4. The Scanning Electron Microscope (SEM) was used to observe the morphological changes of strains exposed to each nanoparticle. Results: Minimum Inhibitory Concentration (MIC) of nanoparticles of all strains was in the concentration range of 0.125 to 0.5 µg/Ml. The synthesized Ag-NPs showed superior antifungal activity against (C. glabrata) compared to Se-NPs and Au-NPs. The scanning electron microscope images revealed the difference in the fungal morphology between the untreated and treated fungi with nanoparticles. Conclusion: The Ag-NPs, followed by Se-NPs synthesized, revealed significant antifungal activity against resistance regardless of their antifungal-resistant mechanisms. [ABSTRACT FROM AUTHOR]