Our objective was to identify whether associations between early food sensitization, aeroallergen sensitization, or food allergy (FA) and the subsequent risk of ARD by age 10 were modified by the development of early AD by age 2 years. However, among those without AD by age 2, perennial aeroallergen sensitization was associated with an increased risk of ever having asthma by age 10 (aRR 2.15 (1.06, 4.36), I p i = 0.031). Additionally, recent investigations dispute the theory that the temporal progression of the atopic march occurs in a sequential pattern.[3] Early AD can facilitate allergen sensitization due to a dysfunctional skin barrier.[4] Both aeroallergen and food sensitization have been associated with risk of ARD,[5] but it is less clear whether AD may partially mediate that risk. [Extracted from the article]