Although vast amounts of Real-World Evidence are available from Electronic Health Records, there is little information on current trends in Real-World Data analysis, thus hindering informed decision-making by healthcare professionals. Real World Evidence includes administrative claims, disease or product registries, patient-generated health data, and other digital health technologies. In this study, we review current and relevant developments, as well as guidelines across different countries, to summarize recent advancements and extract valuable insights from the existing literature on Real-World Evidence. [ABSTRACT FROM AUTHOR]