Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity.
- Resource Type
- Article
- Authors
- Thrush, A. Brianne; Dent, Robert; McPherson, Ruth; Harper, Mary‐Ellen
- Source
- FEBS Journal. Oct2013, Vol. 280 Issue 20, p5015-5029. 15p.
- Subject
- *OBESITY treatment
*MITOCHONDRIA
*SKELETAL muscle
*METABOLIC disorders
*WEIGHT loss
*ENERGY metabolism
*MITOCHONDRIAL physiology
- Language
- ISSN
- 1742-464X
Understanding the metabolic factors that contribute to obesity development and weight loss success are critical for combating obesity and obesity-related disorders. This review provides an overview of energy metabolism with a particular focus on mitochondrial function in health and in obesity. Mitochondrial proton leak contributes significantly to whole body energy expenditure and the potential role of energy uncoupling in weight loss success is discussed. We provide evidence to support the hypothesis that differences in energy efficiency are important regulators of body weight and weight loss success. [ABSTRACT FROM AUTHOR]