Altered gut microbiota richness in individuals with a history of lateral ankle sprain.
- Resource Type
- Article
- Authors
- Terada, Masafumi; Uchida, Masataka; Suga, Tadashi; Isaka, Tadao
- Source
- Research in Sports Medicine. Nov/Dec2023, Vol. 31 Issue 6, p719-733. 15p.
- Subject
- *RNA analysis
*SEQUENCE analysis
*CONFIDENCE intervals
*GUT microbiome
*BACTEROIDES
*ONE-way analysis of variance
*SPRAINS
*SPORTS injuries
*WORLD health
*CASE-control method
*ANKLE injuries
*FECES
*COMPARATIVE studies
*T-test (Statistics)
*DESCRIPTIVE statistics
*RESEARCH funding
*DATA analysis software
*GRAM-positive bacteria
*DISEASE complications
- Language
- ISSN
- 1543-8627
This study aimed to examine differences in the intestinal microbiota diversity in individuals with and without a history of a lateral ankle sprain (LAS). Fifty male college student athletes with (n=32) and without (n=18) a LAS history participated in this study. Faecal samples were collected in the morning after awakening during an off-season, and faecal microbiota were characterized via bacteria 16S rRNA amplicon sequencing. Alpha-diversity metrics and ß-diversity indices were calculated to assess the gut microbiota diversity. The LAS-history group significantly had lower Chao1 (p=0.020) and abundance-based coverage estimators (p=0.035) indices compared to the control group. Gut microbiota composition was not significantly different between athletes with a LAS history and controls (R2 =0.01, p 0.414). Athletes with a history of LASs had significantly higher proportions of Bacteroides Fragilis (p=0.024) and Ruminococcus Gnavus (p=0.021) compared with controls. The gut microbiota of athletes with a LAS history had less richness compared to controls, indicating potential associations between a LAS and the gut microbiota. This study highlights the potential link of a LAS to global health. This study may help raise awareness of strategies to prevent long-term health-related negative consequences in people suffering from LASs. [ABSTRACT FROM AUTHOR]