Determining the Direction of Human Immunodeficiency Virus Transmission: Benefits and Potential Harms of Taking Phylogenetic Analysis One Step Further.
- Resource Type
- Article
- Authors
- Taylor, Barbara S; Sapién, Hugo
- Source
- Clinical Infectious Diseases. Jan2021, Vol. 72 Issue 1, p38-40. 3p.
- Subject
- *HIV prevention
*INFECTIOUS disease transmission
*COMPARATIVE studies
*GENOMES
*HIV
*RESEARCH methodology
*MEDICAL ethics
*MOLECULAR diagnosis
*PHYLOGENY
- Language
- ISSN
- 1058-4838
The article discusses phylogenetic studies of role of human immunodeficiency virus (HIV) transmission dynamics to address HIV epidemic. Topics discussed include use of phyloscanner to infer linkage and direction of transmission of overlapping windows covering the entire HIV genome; use of surveillance strategies to construct phylogenies based on single, incomplete sequences of the pol gene derived from HIV genotype testing; and impact of stigma and discrimination to promote HIV testing.