Gold(III)-Catalyzed Propargylic Substitution Reaction Followed by Cycloisomerization for Synthesis of Poly-Substituted Furans from N -Tosylpropargyl Amines with 1,3-Dicarbonyl Compounds.
- Resource Type
- Article
- Authors
- Morita, Nobuyoshi; Uchida, Shingo; Chiaki, Hitomi; Ishii, Naho; Tanikawa, Kentaro; Tanaka III, Kosaku; Hashimoto, Yoshimitsu; Tamura, Osamu
- Source
- Molecules. Jan2024, Vol. 29 Issue 2, p378. 13p.
- Subject
- *SUBSTITUTION reactions
*FURANS synthesis
*CYCLOISOMERIZATION
*AMINES
*FURAN derivatives
*GOLD
*GOLD catalysts
- Language
- ISSN
- 1420-3049
The treatment of N-tosylpropargyl amines 1 with 1,3-dicarbonyl compounds 2 in the presence of AuBr3 (5 mol%) and AgOTf (15 mol%) afforded poly-substituted furans 3 in good-to-high yields via the gold-catalyzed cleavage of the sp3 carbon–nitrogen bond. [ABSTRACT FROM AUTHOR]