Neurovirulent flavivirus can be attenuated in mice by incorporation of neuron-specific microRNA recognition elements into viral genome.
- Resource Type
- Article
- Authors
- Yen, Li-Chen; Lin, Yi-Ling; Sung, Hsiang-Hsuan; Liao, Jia-Teh; Tsao, Chang-Huei; Su, Chih-Mao; Lin, Chih-Kung; Liao, Ching-Len
- Source
- Vaccine. Dec2013, Vol. 31 Issue 49, p5915-5922. 8p.
- Subject
- *VIRAL vaccines
*VIRAL genomes
*FLAVIVIRUSES
*MICRORNA
*LABORATORY mice
*NEURONS
- Language
- ISSN
- 0264-410X
Highlights: ▶ Cellular microRNA inhibits expression of flaviviral mRNA lacking poly(A). ▶ Brain neurons are major targets of infection by neurotropic flaviviruses. ▶ Inclusion of engineered miRNA recognition elements into genome provides a rational design for safer flavivirus vaccines. [Copyright &y& Elsevier]