Th17 pathway signatures in a large Indian cohort of Guillain Barré syndrome.
- Resource Type
- Article
- Authors
- Debnath, Monojit; Nagappa, Madhu; Subbanna, Manjula; Sundaravadivel, Pandarisamy; Talukdar, Pinku Mani; Shivakumar, Venkataram; Wahatule, Rahul; Dutta, Debprasad; Binukumar, B.; Sinha, Sanjib; Bindu, Parayil Sankaran; Periyavan, Sundar; Umamaheswara Rao, G.S.; Taly, Arun B.
- Source
- Journal of Neuroimmunology. Oct2018, Vol. 323, p125-130. 6p.
- Subject
- *GENE expression
*GUILLAIN-Barre syndrome
*SINGLE nucleotide polymorphisms
*RESTRICTION fragment length polymorphisms
*GENETICS
*PATIENTS
- Language
- ISSN
- 0165-5728
Abstract The etiopathogenesis of Guillain Barré Syndrome (GBS) is inadequately understood. The role of immuno-inflammatory Th17 pathway was examined in GBS patients by genetic, gene expression and biochemical studies. Genotyping of G197A single nucleotide polymorphism within IL17 gene was carried out by PCR-RFLP method in 220 GBS patients. Quantification of gene expression of STAT3 and RORC and estimation of plasma level of IL-17A were carried out in a subset of patients. Significantly increased STAT3 gene expression in lymphocytes and plasma IL-17A levels were observed in GBS patients. This study adds new dimension and reinforces important implications of Th17 pathway in GBS. Graphical abstract Unlabelled Image Highlights • Th17 pathway may crucially drive immunopathogenesis of GBS. • Increased STAT3 gene expression might regulate Th17 cell activity in GBS. • Elevated plasma IL-17A level might mediate the effector function of Th17 cells in GBS. [ABSTRACT FROM AUTHOR]