Catalyst- and solvent-free bisphosphinylation of isothiocyanates: a practical method for the synthesis of bisphosphinoylaminomethanes.
- Resource Type
- Article
- Authors
- Wen, Li-Rong; Sun, Yong-Xu; Zhang, Jin-Wei; Guo, Wei-Si; Li, Ming
- Source
- Green Chemistry. 1/7/2018, Vol. 20 Issue 1, p125-129. 5p.
- Subject
- *ISOTHIOCYANATES
*METHANE synthesis
*PHOSPHINE oxides
- Language
- ISSN
- 1463-9262
A general and convenient double addition of phosphine oxides to isothiocyanates is described. It is a practically useful protocol for the construction of bisphosphinoylaminomethanes. The reaction can be carried out smoothly under metal- and solvent-free conditions. It also features a broad substrate scope, simple operation and purification. A possible mechanism involving a tandem double nucleophilic addition/H2S elimination/in situ imine reduction process is proposed. [ABSTRACT FROM AUTHOR]