Two new alkaloids produced by Dothideomycetes sp. BMC-101 isolated from the Magnolia grandiflora.
- Resource Type
- Article
- Authors
- Wang, Lu-Sheng; Zong, Shi-Kun; Wu, Ping-Ping; Sun, Xiao-Long; Wu, Cheng-Zhu; Wang, Hao-Tian; Zhu, Mei-Lin
- Source
- Journal of Asian Natural Products Research. Aug2023, Vol. 25 Issue 8, p731-740. 10p.
- Subject
- *EXPERIMENTAL design
*NASOPHARYNX cancer
*ADENOCARCINOMA
*LUNG cancer
*PHENYLALANINE
*HIGH performance liquid chromatography
*ALKALOIDS
*FUNGI
*ANTINEOPLASTIC agents
*NUCLEAR magnetic resonance spectroscopy
*RESEARCH funding
*TOXICITY testing
*CELL lines
*MOLECULAR structure
*BREAST tumors
*METABOLITES
*PHARMACODYNAMICS
- Language
- ISSN
- 1028-6020
A total of 16 fungal strains were isolated from fresh leaves and flowers of Magnolia grandiflora and the EtOAc extracts of them were assayed for antitumor activities. Among these, the fungus Dothideomycetes sp. BMC-101 with broad spectrum inhibition was selected for further study. Four alkaloids (1–4) including two new compounds (2-(hydroxyimino)-3-phenylpropanoyl)-L-phenylalanine (1) and 8-Acetyl-bisdethiobis(methylsulfanyl)apoaranotin (4)) were isolated from Dothideomycetes sp. BMC-101. The structure of 1 was characterized with an oxime moiety formed by the condensation of two phenylalanines. To our knowledge, this is the first report on a fungal phenylalanine derivative with an oxime moiety. [ABSTRACT FROM AUTHOR]