In the present investigation, biocorrosion behaviour of novel Mg-based multicomponent low-entropy alloy (Mg70Al18Zn6Ca4Y2 LEA), fabricated using disintegrated melt deposition technique has been evaluated. The electrochemical behaviour of this Mg LEA alloy at different simulated body fluid solutions, such as [artificial blood plasma (ABP), pH 7.4], [phosphate buffer saline (PBS), pH 7.4], [Hank's balanced salt solution (HBSS), pH 7.4] and artificial saliva solution (ASS, pH 6.2) has been studied using Potentio-dynamic polarization test followed by qualitative analysis attained from electrochemical impedance spectroscopy (EIS). Further, the surfaces of the corroded samples were examined using scanning electron microscopy and its chemical composition were analysed using energy-dispersive X-ray spectroscopy. The results show significant passive behaviour and improved corrosion resistance for sample in ASS solution compared to the ABP, PBS and HBSS. The rank of the Mg LEA alloy based on the corrosion resistance is in the following order: ABP