We report a systematic investigation on the evolution of the structural and physical properties, including the charge density wave (CDW) and superconductivity of the polycrystalline CuIr2Te4−xIx for 0.0 ≤ x ≤ 1.0. X-ray diffraction results indicate that both of a and c lattice parameters increase linearly when 0.0 ≤ x ≤ 1.0. The resistivity measurements indicate that the CDW is destabilized with slight x but reappears at x ≥ 0.9 with very high TCDW. Meanwhile, the superconducting transition temperature Tc enhances as x increases and reaches a maximum value of around 2.95 K for the optimal composition CuIr2Te1.9I0.1 followed by a slight decrease with higher iodine doping content. The specific heat jump (ΔC/γTc) for the optimal composition CuIr2Te3.9I0.1 is approximately 1.46, which is close to the Bardeen–Cooper–Schrieffer value of 1.43, indicating that it is a bulk superconductor. The results of thermodynamic heat capacity measurements under different magnetic fields [Cp(T, H)], magnetization M(T, H) and magneto-transport ρ(T, H) measurements further suggest that CuIr2Te4−xIx bulks are type-II superconductors. Finally, an electronic phase diagram for this CuIr2Te4−xIx system has been constructed. The present study provides a suitable material platform for further investigation of the interplay of the CDW and superconductivity. [ABSTRACT FROM AUTHOR]