A urinary metabonomics study on biochemical changes in yeast-induced pyrexia rats: A new approach to elucidating the biochemical basis of the febrile response.
- Resource Type
- Article
- Authors
- Gao, Xiaoyan; Guo, Mingxing; Zhao, Baosheng; Peng, Long; Su, Jiankun; Bai, Xu; Li, Jun; Qiao, Yanjiang
- Source
- Chemico-Biological Interactions. Jun2013, Vol. 204 Issue 1, p39-48. 10p.
- Subject
- *YEAST fungi biotechnology
*FEVER
*LABORATORY rats
*PYROGENS
*TRYPTOPHAN metabolism
*CYCLIC adenylic acid
- Language
- ISSN
- 0009-2797
Highlights: [•] The pathway of “endogenous pyrogen (EP)-hypothalamus Na+/Ca2+-cAMP↑” was supported by this study. [•] Tryptophan metabolism plays an important role in fever. [•] Metabonomics could be a promising tool for explaining the pathogenesis of disease. [Copyright &y& Elsevier]