Dear Editor, A 41-year-old woman with a history of asthma was admitted with acute onset of a diffuse painful nonpruritic rash with cephalocaudal progression. Complete resolution of the facial lesions following high-dose corticosteroid therapy (d) gl Despite IV acyclovir, the patient continued to clinically deteriorate. Fibrin deposition and neutrophils were noted within the vessel walls consistent with leukocytoclastic vasculitis (b, Hematoxylin-eosin stain ×40) gl Upon review of the literature and a previously reported case of false-positive HSV DFA in a patient with severe eosinophilia, it was decided to stop IV acyclovir and start high-dose corticosteroids for a working diagnosis of eosinophilic granulomatosis with polyangiitis (EGPA). [Extracted from the article]