Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy.
- Resource Type
- Article
- Authors
- Vornholz, Larsen; Isay, Sophie E.; Kurgyis, Zsuzsanna; Strobl, Daniel C.; Loll, Patricia; Mosa, Mohammed H.; Luecken, Malte D.; Sterr, Michael; Lickert, Heiko; Winter, Christof; Greten, Florian R.; Farin, Henner F.; Theis, Fabian J.; Ruland, Jürgen
- Source
- Science Advances. 3/17/2023, Vol. 9 Issue 11, p1-17. 17p.
- Subject
- *IMMUNE checkpoint inhibitors
*DNA mismatch repair
*PROGRAMMED cell death 1 receptors
*CANCER cells
*CELL communication
*T cell receptors
*COMPUTATIONAL biology
*VENOM
*GENE expression
- Language
- ISSN
- 2375-2548
The article presents a study which explores how synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy. It mentions the results of the study that introduce a rational strategy for modulating cancer cell–intrinsic programs via engineered STING enforcement to sensitize resistant tumors to Immune checkpoint inhibitors (ICIs) responsiveness.