Specificities of acute cholangitis in patients with cancer: a retrospective comparative study of 130 episodes.
- Resource Type
- Article
- Authors
- Sokal, Aurélien; Chawki, Sylvain; Nguyen, Yann; Sauvanet, Alain; Ponsot, Philippe; Maire, Frédérique; Fantin, Bruno; de Lastours, Victoire
- Source
- European Journal of Clinical Microbiology & Infectious Diseases. Jan2022, Vol. 41 Issue 1, p143-146. 4p.
- Subject
- *CHOLANGITIS
*BILE ducts
*CANCER patients
*PANCREATIC duct
*DRUG resistance in bacteria
*COMPARATIVE studies
- Language
- ISSN
- 0934-9723
Pancreatic and biliary duct cancers are increasing causes of acute cholangitis (AC). We retrospectively characterize 81 cancer-associated cholangitis (CAC) compared to 49 non-cancer-associated cholangitis (NCAC). Clinical and biological presentations were similar. However, in CAC, antibiotic resistance and inadequate empirical antibiotic therapy were more frequent; more patients required ≥ 2 biliary drainages; and mortality at day 28 was higher than in NCAC. Death was associated with initial severity and CAC in a multivariate analysis. Cholangitis associated with pancreatic or biliary duct cancers requires specific empirical antimicrobial therapy; early use of biliary drainage may improve outcomes. [ABSTRACT FROM AUTHOR]