CASE REPORT OF PARATHYROID CARCINOMA IN AN END STAGE RENAL DISEASE PATIENT.
- Resource Type
- Article
- Authors
- Buzejic, Matija; Slijepcevic, Nikola; Zivaljevic, Vlada; Zoric, Goran; Odalovic, Bozidar; Tausanovic, Katarina; Rovcanin, Branislav; Jovanovic, Milan; Vucen, Duska; Stepanovic, Boban; Paunovic, Ivan
- Source
- Medical Gazette / Medicinski Glasnik. dec2019, Vol. 24 Issue 75, p15-22. 8p.
- Subject
- *CHRONIC kidney failure
*JAW tumors
*RENAL cell carcinoma
*PATHOLOGY
*CARCINOMA
- Language
- ISSN
- 1821-1925
Introduction: Parathyroid carcinoma is a rare endocrine tumor and among the rarest of all malignancies in human population. Especially rare entity is parathyroid carcinoma in patient with end stage renal disease who receive hemodialysis. Pathogenesis of parathyroid hyperplasia in patients who receive hemodialysis is well known but on the other side pathogenesis of parathyroid carcinoma in those patients is still unknown. We present a case of parathyroid carcinoma in patient with secondary hyperparathyroidism. Case outline : A 67-year-old female on maintenance hemodialysis for 48 months was admitted to our hospital in April 2018 for the operation for a palpable neck mass. She developed end stage renal disease after two kidney operations due to Renal Cell Carcinoma. Level of parathyroid hormone was 1022 ng/L which is significantly higher above normal range, even do she was using vitamin D analogs. Ultrasonography revealed an isoechoic nodule in the left lobe of the thyroid gland measuring 27x29x29 mm. Lower left parathyroidectomy was performed along with ipsilateral lobectomy due to its infiltration. Histological analysis confirmed presence of parathyroid carcinoma. Plasma PTH level decreased on the second day to 56 ng/L Conclusion: After surgical treatment patient was normocalcemic with significant reduce of PTH level. In patients with secondary hyperparathyroidism who develop parathyroid carcinoma parathyroidectomy represents only definitive kind of treatment. [ABSTRACT FROM AUTHOR]