SWI/SNF regulation of germinal center fate and lymphomagenesis.
- Resource Type
- Article
- Authors
- Sievers, Quinlan; Abdel-Wahab, Omar
- Source
- Cancer Cell. Apr2024, Vol. 42 Issue 4, p507-509. 3p.
- Subject
- *GERMINAL centers
*B cells
*LYMPHOMAS
- Language
- ISSN
- 1535-6108
The mSWI/SNF subunits ARID1A and SMARCA4 are mutated in B cell lymphomas. Now, Barisic et al. and Deng et al. find that loss of ARID1A or SMARCA4 contributes to lymphomagenesis by causing B cells to aberrantly re-enter germinal centers where they undergo repeated rounds of proliferation and somatic hypermutation. [ABSTRACT FROM AUTHOR]