In this article, we aim to investigate the path following control problem for four-wheel-independent-drive electric vehicles with consideration of modeling errors and complex driving scenarios. In order to guarantee operational safety and robustness, a supertwisting second-order sliding mode (SOSM) control strategy is employed to suppress the heavy chattering issue existing in the traditional sliding mode control (SMC). To degrade the lumped disturbance, a nonlinear disturbance observer (NDOB) technique is proposed to estimate the disturbance and compensate the modeling error. Then, a composite control strategy, which combines the SMC algorithm and NDOB technique is proposed based on stability analysis of the corresponding closed-loop system. Finally, hardware-in-the-loop experimental results show that the supertwisting SOSM control algorithm with the NDOB technique can achieve better tracking performance and suppress the chattering phenomenon. [ABSTRACT FROM AUTHOR]