Ubiquitination of BAT3-captured proteins is required for efficient protein degradation.8 Under cisplatin treatment and proteasomal degradation blockage, BAT3 co-immunoprecipitated with UBQLN4 in I UBQLN4 i -OV and parental cell lines (Figure S3C,D,F,G). Co-localisation of UBQLN4-STING, UBQLN4-BAT3 and STING-BAT3 are indicated in yellow. Importantly, UBQLN4 co-immunoprecipitated with STING during both the presence/absence of BAT3, suggesting a BAT3-independent UBQLN4-STING interaction (Figure 2K). UBQLN4 promotes STING proteasomal degradation during cisplatin-induced DNA damage in triple-negative breast cancer. [Extracted from the article]