A field trial was conducted at the Agronomic Research Area, Department of Agronomy, University of Agriculture, Faisalabad, Pakistan to assess the influence of combined nutrients use on yield and quality of sunflower (Helianthus annuus L.). Treatments were i) control;, ii) recommended dose of fertilizer (RDF); iii) single spray of multi nutrients at V44 stage (four leaves stage); iv) RDF+1 spray of multi nutrients at V44 stage; v) 2 spray of multi nutrients at V44 and V8 stages; vi) RDF+2 spray of multi nutrients at V44 and V8 stages; vii) three spray of multi nutrients at V44, V8 and V12 stages; viii) RDF+ 3 spray of multi nutrients at V44, V8 and V12 stages. Multi nutrients Zn (4.7%), Mn (2%), Fe (2%), B (1%) and Cu (0.3%) were applied at the rate of 1.25 L/ha. Nitrogen was used in three splits i.e. half at sowing time, 1/4 at 1st irrigation and remaining 1/4 at flowering. While, phosphorus and potassium were used at sowing. Results showed that 1000-achene weight (48.80g), Stem diameter (3.08 cm), number of achene per head (1005.50), head diameter (14.92 cm) and achene yield (2900 kg ha-1) was significantly higher in the treatment (T8) where RDF +3 sprays of multi nutrients (1.25L/ha at V44, 1.25L/ha at V8 and 1.25L/ha at V12 stages) were applied. It was concluded that N-P-K at the rate of 110-57-62 kg/ha + three sprays of multi nutrients (Zn 4.7%, Mn 2%, Fe 2%, B 1% and Cu 0.3%) applied at the rate of 1.25 L/ha at V44 (four true leaves), V8 (Eight true leaves) and V12 (twelve true leaves) stages of sunflower (Hysun 33) gave the best yield under agro-climatic conditions of Faisalabad, Pakistan. [ABSTRACT FROM AUTHOR]