This document highlights the challenges of diagnosing and treating unexplained infertility in heterosexual couples, emphasizing the need for advancements in diagnostic tests and individualized decision-making. The document also mentions a study that found intrauterine insemination with ovarian stimulation (IUI-OS) to be more effective in achieving live births compared to expectant management. It emphasizes the importance of accurately assessing coital frequency and timing, considering lifestyle factors, and developing better diagnostic tools. Further research is needed to improve treatment options and prognostic models for unexplained infertility. [Extracted from the article]