Formation of 5-Aminomethyl-2,3-dihydropyridine-4(1 H)-ones from 4-Amino-tetrahydropyridinylidene Salts.
- Resource Type
- Article
- Authors
- Seebacher, Werner; Hoffelner, Michael; Belaj, Ferdinand; Pirker, Teresa; Alajlani, Muaaz; Bauer, Rudolf; Pferschy-Wenzig, Eva-Maria; Saf, Robert; Weis, Robert
- Source
- Molecules. Oct2023, Vol. 28 Issue 19, p6869. 19p.
- Subject
- *SALTS
*SINGLE crystals
*CRYSTAL structure
*ALDEHYDES
- Language
- ISSN
- 1420-3049
Various 4-aminotetrahydropyridinylidene salts were treated with aldehydes in an alkaline medium. Their conversion to 5-substituted β-hydroxyketones in a one-step reaction succeeded only with an aliphatic aldehyde. Instead, aromatic aldehydes gave 5-substituted β-aminoketones or a single δ-diketone. The new compounds were characterized using spectroscopic methods and a single crystal structure analysis. Some of them showed anticancer and antibacterial properties. [ABSTRACT FROM AUTHOR]