Recently, genome-wide DNA methylation profiles of JMML and NS patients identified distinct methylation signatures correlating with clinical and genetic features and survival (Lipka I et al i , [4]; Stieglitz I et al i , [8]). By contrast, all other NS-MPD patients clustered in the LM group, whereas no JMML patients with monosomy 7 clustered in the LM group. Importantly, the later profiles from our patient resemble JMML patients with monosomy 7 more than NS-MPD. Altogether, we demonstrated that the aberrant methylation profile in our case of NS-MPD with monosomy 7 closely resembled methylation profiles seen in JMML cases with monosomy 7 and clearly differed from NS-MPD with normal karyotype. [Extracted from the article]