Global trends in antiretroviral resistance in treatment-naive individuals with HIV after rollout of antiretroviral treatment in resource-limited settings: a global collaborative study and meta-regression analysis.
- Resource Type
- Article
- Authors
- Gupta, Ravindra K.; Jordan, Michael R.; Sultan, Binta J.; Hill, Andrew; Davis, Daniel H. J.; Gregson, John; Sawyer, Anthony W.; Hamers, Raph L.; Ndembi, Nicaise; Pillay, Deenan; Bertagnolio, Silvia
- Source
- Lancet. 10/6/2012, Vol. 380 Issue 9849, p1250-1258. 9p.
- Subject
- *DRUG resistance
*HIV infections
*ANTIRETROVIRAL agents
*NON-nucleoside reverse transcriptase inhibitors
- Language
- ISSN
- 0140-6736
The article presents information on a study for the estimation of changes in the prevalence of HIV-1 drug resistance in drug naive individuals with HIV infection since commencement of rollout of antiretroviral treatment in resource-limited settings. The findings show a considerable increase in prevalence of drug resistance since antiretroviral rollout in regions of sub-Saharan Africa which is driven by Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) resistance.