170: METASTATIC MYOCARDIAL CALCINOSIS FROM PEMBROLIZUMAB-INDUCED ACUTE RENAL AND RESPIRATORY FAILURE.
- Resource Type
- Article
- Authors
- Satterfield, Benjamin; Anavekar, Nandan
- Source
- Critical Care Medicine. 2019 Supplement, Vol. 47, p67-67. 1p.
- Subject
- *ACUTE kidney failure
*ADULT respiratory distress syndrome
*CALCINOSIS
*KIDNEY failure
*INTERSTITIAL lung diseases
*CHRONIC kidney failure
*CHRONIC lymphocytic leukemia
- Language
- ISSN
- 0090-3493
B Learning Objectives: b Pembrolizumab-induced acute kidney injury and acute lung interstitial disease are both phenomena that have been described since the drug's availability on the market in late 2016. We describe the deposition of metastatic myocardial calcinosis during an event of acute renal failure in a patient recently started on Pembrolizumab. Surprisingly, his functional status remained excellent despite the metastatic calcinosis that appears to have occurred during his hospitalization, likely due to Pembrolizumab-induced acute renal failure causing hyperphosphatemia and subsequent precipitation of calcium in the myocardium. [Extracted from the article]