Erythropoietin Mimetics Derived from Solution Phase Combinatorial Libraries.
- Resource Type
- Article
- Authors
- Goldberg, Joel; Qing Jin; Ambroise, Yves; Satoh, Shigeki; Desharnais, Joel; Capps, Kevin; Boger, Dale L.
- Source
- Journal of the American Chemical Society. 1/30/2002, Vol. 124 Issue 4, p544. 12p. 16 Diagrams, 5 Charts, 8 Graphs.
- Subject
- *ERYTHROPOIETIN
*LIGANDS (Chemistry)
- Language
- ISSN
- 0002-7863
Examines the derivation of erythropoietin mimetics from solution phase combinatorial libraries. Activation of the erythropoietin receptor (EPOr) by ligand-induced homodimerization; Identification novel small molecule binders of EPOr in a protein binding assays; Mechanism of cytokine activation.