The intrinsically disordered SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a.
- Resource Type
- Article
- Authors
- Bessa, Luiza Mamigonian; Guseva, Serafima; Camacho-Zarco, Aldo R.; Salvi, Nicola; Maurin, Damien; Perez, Laura Mariño; Botova, Maiia; Malki, Anas; Nanao, Max; Jensen, Malene Ringkjøbing; Ruigrok, Rob W. H.; Blackledge, Martin
- Source
- Science Advances. 1/21/2022, Vol. 8 Issue 3, p1-12. 12p.
- Subject
- *SARS-CoV-2
*MERS coronavirus
*HEAT shock proteins
- Language
- ISSN
- 2375-2548
The article presents a study that explores the intrinsically disordered SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a. It mentions about the processes of genome replication and transcription of SARS-CoV-2 represent important targets for viral inhibition. It discusses the identification of distinct linear motifs that mediate an important interaction between essential viral factors provides future targets for development of innovative strategies against Covid-19.