This article discusses a study that used a combined multi-omics approach to investigate the genetic and epigenetic factors underlying testicular cancer in a family trio. The study identified pathogenic germline variations in the ELAC2 and CHEK2 genes, inherited from the father and mother respectively. Additionally, differential methylation patterns were observed in specific DNA segments, suggesting a role in carcinogenesis. The study aimed to identify pathogenic variants and epigenetic changes related to early onset of testicular cancer. However, the study is limited to a trio-case study, and further research is needed to investigate the links between methylation and gene expression. [Extracted from the article]