Background: Tobacco use is the leading single preventable cause of deaths worldwide. Present study was focused on the cessation of tobacco consumption through a range of behavioural and pharmacological therapies. Material and Methods: Prospective self-control quasi experimental study utilizing WHO 5A's and 5R's method of behavioural intervention for tobacco cessation. Results: 150 patients were enrolled for the study. 95 participants successfully quit tobacco, 16 and 9 patients restarted before and after one month and 23 patients did not quit. 8 patients were lost to follow-up. Presence of withdrawal symptoms was significantly associated with reuse of tobacco (p-value 0.0018*). Conclusion: WHO 5A's and 5R's method of tobacco cessation counselling was found to be effective in quitting tobacco. [ABSTRACT FROM AUTHOR]