The article discusses the impact of stress combinations on plants and ecosystems. It highlights the increasing frequency and intensity of stress combinations due to global warming and climate change. The special issue includes research papers, resource papers, and reviews that explore various aspects of plant responses to stress combinations. Topics covered include the role of transcription factors, morphological and physiological responses, genetic variations, and the interactions between different stresses. The article emphasizes the importance of understanding plant responses to stress combinations in order to develop resilient crops in the face of climate change and pollution. [Extracted from the article]