This article in Advanced Synthesis & Catalysis presents a green and efficient method for synthesizing fused pyrimidinediones using a cascade Wolff rearrangement and double N-acylation reaction. The protocol eliminates the need for catalysts and additives, as well as traditional purification methods like organic solvent extraction and column chromatography. The authors demonstrate the potential applications of this reaction by synthesizing biologically active molecules and conducting gram-scale experiments. The details of the protocol can be found in the communication by Yan-Ping Zhu, Wei Zhu, and their co-workers. [Extracted from the article]